教师名录

【研究方向】

脑分子、细胞神经退化机制；神经可塑性与痴呆；运动脑健康、老化与神经环路调节

【办公地点】生科院C511

【联系邮箱】jswei@henu.edu.cn

【教育及工作经历】

教育经历：

1988-1993新乡医学院，获医学学士学位；

1993-1996成都体育学院/国家体委体科所医学病理研究室，获教育学硕士学位；

1999-2002 复旦大学上海医学院，获神经生物学理学博士学位

工作经历：

1996-1999BetWay体育平台体育学院，人体与运动生理学助教、讲师；

2003-2004 加拿大卡尔加里大学医学院，博士后及研究助理；

2004 -2009日本东京都医学科学研究所，常勤研究员；

2009-2010纽约州发育障碍基础研究院/纽约市立大学神经化学系助理研究科学家；

2010.09-至今BetWay体育平台，betway88西汉姆网页，特聘教授/教授

【代表性论文】(近五年) (#通讯作者)

1. Anyomi BK, Fosu K, Lamptey EL, Agegnehu SB, Emmanuel L, Quarshie JT, Kampo S, Wei J#. Decreased Expression of Alzheimer’s Disease-Related Genes in Cancer May Contribute to the Inverse Relationship-a Computational Study. ACS Omega, 2025 April 24 online.

2. Kong X, Liu T, Wei J#. Parkinson's Disease: The Neurodegenerative Enigma Under the "Undercurrent" of Endoplasmic Reticulum Stress. Int J Mol Sci. 2025 Apr 3;26(7):3367.

3. Zhang J, Liu T, Wu H, Wei J#, Qu Q#. Target oxidative stress-induced disulfidptosis: novel therapeutic avenues in Parkinson's disease. Mol Brain. 2025 Apr 4;18(1):29.

4. Li J, Liu T, Xian M, Zhou K#, Wei J#. The Power of Exercise: Unlocking the biological Mysteries of Peripheral-Central crosstalk in Parkinson's disease. J Adv Res. 2025 Mar 4: S2090-1232(25)00143-2. Online ahead of print.

5. Liu T, Wu H and Wei J#. Molecular insights into Parkinson's disease and type 2 diabetes mellitus: Metformin's role and genetic pathways explored. Exp Neurol., 2025 Mar; 385: 115137.

6. Liu S, Liu T, Li J, Hong J, Moosavi-Movahedi AA, Wei J#. Type 2 diabetes mellitus exacerbates pathological processes of Parkinson's disease: insights from signaling pathways mediated by insulin receptors. Neurosci Bull., 2025 Apr; 41(4):676-690.

7. Liu T, Wu H, Li J, Zhu C, Wei J#. Unraveling the Bone-Brain Axis: A New Frontier in Parkinson’s Disease Research. Int J Mol Sci., 2024 Nov 29; 25(23):12842.

8. Li J, Kong X, Liu T, Xian M, Wei J#. The Role of ACE2 in Neurological Disorders: From Underlying Mechanisms to the Neurological Impact of COVID-19. Int J Mol Sci. 2024 Sep 15;25(18):9960.

9. Liu T, Li J, Sun L#, Zhu C, Wei J#. The role of ACE2 in RAS axis on microglia activation in Parkinson's disease. Neuroscience. 2024 Aug 16; 553:128-144.

10. Xian M, Li J, Liu T, Hou K, Sun L#, Wei J#. β-Synuclein Intermediates α-Synuclein Neurotoxicity in Parkinson's Disease. ACS Chem Neurosci. 2024 Jul 3;15(13):2445-2453.

11. Liu T, Wu H, Sun L#, Wei J#. Role of Inflammation in the Development of COVID-19 to Parkinson's Disease. J Inflamm Res. 2024 May 21; 17:3259-3282.

12. Han T, Xu Y, Liu H, Sun L#, Cheng X, Shen Y, Wei J#. Function and Mechanism of Abscisic Acid on Microglia-Induced Neuroinflammation in Parkinson's Disease. Int J Mol Sci. 2024 Apr 30; 25(9):4920.

13. Xu Y, Li Y, Wang C, Han T, Wu Y, Wang S #, Wei J #. Clinical value and mechanistic analysis of HIIT on modulating risk and symptoms of depression: a systematic review. Int J Clin Health Psychol. 2024 Jan-Mar; 24(1): 100433.

14. Han T, Xu Y, Sun L, Hashimoto M, Wei J#. Microglial response to aging and neuroinflammation in the development of neurodegenerative diseases. Neural Regen Res. 2024 Jun 1;19(6):1241-1248.

15. Chu J, Li J, Sun L#, Wei J#. The Role of Cellular Defense Systems of Ferroptosis in Parkinson’s Disease and Alzheimer’s Disease. Int. J. Mol. Sci. 2023; 24(18), 14108.

16. Hou K, Liu T, Li J, Xian M, Sun L#, Wei J#. Liquid-liquid phase separation regulates alpha-synuclein aggregate and mitophagy in Parkinson's disease. Front. Neurosci., 2023; 17:1250532.

17. Liu T, Hou K, Li J, Han T, Liu S, Wei J#. Alzheimer’s Disease and Aging Association: Identification and Validation of Related Genes. JPAD - J Prev Alz Dis 2024; 11(1):196-213.

18. Liu Y#, Wei J#. Research on Brain and Mind Inspired Intelligence. International Journal of Interactive Multimedia and Artificial Intelligence. 2023; 8(4): 17-32.

19. Li J, Xu Y, Liu T, Xu Y, Zhao X, Wei J#. The Role of Exercise in Maintaining Mitochondrial Proteostasis in Parkinson’s Disease. Int. J. Mol. Sci. 2023; 24(9), 7994.

20. Liu T, Yang Z, Liu S, Wei J#. Parkinson's Disease as a Risk Factor for Prostate Adenocarcinoma: A Molecular Point of View. Gerontology. 2023; 69(8):986-1001.

21. Zhou L, Wang K, Xu Y, Dong BB, Wu DC, Wang ZX, Wang XT, Cai XY, Yang JT, Zheng R, Chen W#, Shen Y#, Wei JS#. A patient-derived mutation of epilepsy-linked LGI1 increases seizure susceptibility through regulating Kv1.1. Cell Biosci. 2023; 13(1):34.

22. Xu Y, Li Y, Wang C, Han T, Liu H, Sun L, Hong J, Hashimoto M, Wei J#. The reciprocal interactions between microglia and T cells in Parkinson's disease: a double-edged sword. J Neuroinflammation. 2023; 20(1):33.

23. Yang Y, Wang G, Zhang S, Wang H, Zhou W, Ren F, Liang H, Wu D, Ji X, Hashimoto M, Wei J#. Efficacy and evaluation of therapeutic exercises on adults with Parkinson's disease: a systematic review and network meta-analysis. BMC Geriatr. 2022; 22(1):813.

【项目/著作/专利】

项目：

河南省医学科技攻关计划（252102311160）2025-2026，有氧运动延缓帕金森病神经功能机制研究

河南省卫生健康委员会重点项目(SBGJ202402075)2025-2027, 帕金森病神经变性与内质网应激机制研究

国家自然科学基金国际合作重点项目(32161143021)2022-2025，油菜籽抗氧化物对糖尿病及其并发症影响和功能油菜的研究，神经微血管病变子课题

BetWay体育平台医学交叉前沿学科项目(CJ1205A0240018)2020-2021，基于神经环路的抑郁症干预机理研究

河南省自然科学基金项目(182300410313)2018-2019，光遗传技术调控突触核蛋白介导抑郁症神经环路重塑分子机理

国家自然科学基金面上项目(81271410)2013-2016，帕金森病相关蛋白parkin对突触核蛋白降解的调控作用及其致病机制

BetWay体育平台黄河学者科研创新基金(0000A50055)2011-2016，帕金森病蛋白质降解基础研究

专著章节：

1. Liu Z, Li P, Wu J, Wang Y, Li P, Hou X, Zhang Q, Wei N, Zhao Z, Liang H, Wei J*. 2015. The cascade of oxidative stress and tau protein autophagic dysfunction in Alzheimer’s disease. In: Alzheimer's Disease - Challenges for the Future (Ed. Inga Zerr), InTech, 27-45. ISBN 978-953-51-2137-4

2. Sekigawa A, Fujita M, Sekiyama K, Takamatsu Y, Wei J*, Hashimoto M*. 2011. Gangliosides as a Double-Edged Sword in Neurodegenerative Disease. In: Alzheimer’s Disease - Pathogenesis-Core Concepts, Shifting Paradigms and Therapeutic Targets (Ed. Suzanne De La Monte), InTech, 589-602. ISBN: 978-953-307- 690-4

【教学及人才培养】

《人体生理学》《神经生物学》《高级神经科学教程》《分子神经生物学》《文献阅读》《生物学研究方法与学术规范》

【主要荣誉】

1. 《中小城市社区人群脑卒中主动防治关键技术研究及应用》获2023河南省科学技术进步奖叁等奖

2. 《含有PEST基序的核蛋白促进肿瘤生长的作用机制研究》获2023河南省教育厅科技成果奖